Animalcare Ltd has launched Tilmodil (tilmicosin 300mg/ml solution for injection), a semi-synthetic macrolide antibiotic licensed for pneumonia in cattle and sheep, foul in the foot in cattle, and footrot and mastitis in sheep.

According to the company, Tilmicosin is fast-acting¹, long-acting² and highly effective against the major Gram-ve bovine respiratory pathogens.^2,3 In addition, the company says tissue penetration is excellent.¹ In calves a single SC injection at 10mg/kg bw results in lung concentrations exceeding the MIC­₉₀ of Mannheimia haemolytica for 72 hours.²

Animalcare says that pooled data from greater than 6000 cattle has confirmed the effectiveness of tilmicosin in the treatment of bovine respiratory disease (BRD) in well-controlled, randomised field studies. Tilmodil treatment has been proven equally effective compared to antibiotics, such as florfenicol, marbofloxacin and danofloxacin.

A recent report by the Farm Animal Welfare Council estimates that three million of the national sheep flock are lame at any one time. It is estimated that footrot is responsible for greater than 90% of lameness and is present in 97% of flocks. Tilmicosin has good activity against the key Gram-ve pathogens² and has been successfully used in the treatment of footrot.⁴

Tilmodil has been developed for animal use only and is administered by veterinary surgeons only. Dosage is 1ml per 30kg bw for respiratory disease and mastitis in sheep and 0.5ml per 30kg bw for interdigital necrobacillosis (foul in the foot/footrot/bovine pododermatitis).

Tilmodil is administered as a single, low volume subcutaneous (SC) injection dose and presented in 50ml multi-dose vials.

References

1. Apley M., Antimicrobial therapy of Bovine Respiratory Disease.Veterinary Clinics of North America.Food Animal Practice (1997) 13,3:159-562
2. Tilmodil SPC
3. Giguere S et al .,Antimicrobial therapy in Veterinary Medicine.4^th edition 2006.Chp.12,201
4. Winter A., Lameness in sheep. 2. Treatment and control. In Practice (2004),3, 130-139.

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