According to the charity, FIP, which is one of a number of chronic viral infections of cats that resemble those in people, is estimated to kill up to 1.4% of cats around the world.
The infectious agent is a mutant coronavirus (FIPV) that is notoriously difficult to control: the parent enteric coronavirus is present in virtually all catteries and shelters and is shed by 60% or more of pet cats from multi-cat households,1 and vaccines are ineffective.
Among the most promising treatments against emerging viruses in humans is 'GS-5734', one of the small-molecule antivirals targeting specific proteins involved in RNA virus replication.
In studies, it has proven effective in preventing Ebola in rhesus monkeys and inhibiting coronaviruses both in tissue culture and in mouse infection models.
It was these findings that brought it to the attention of a team of veterinary researchers in the USA, led by Professor Niels Pedersen of the University of California, Davis.
Their own initial studies involving experimental FIP showed that the less chemically complex 'GS-441524', the parent nucleoside of GS-5734, was highly effective, opening the way for a field trial in cats with naturally occurring FIP, the results of which are published in this week's JFMS2.
Thirty-one cats, ranging in age from 3–73 months, were enrolled in the study, and 26 completed the planned 12 weeks or more of treatment; the remainder died or were euthanised due to their severe disease.
For these 26 cats, the clinical response was dramatic: fever usually resolved within 12–36 h, concurrent with a marked improvement in appetite, activity levels and weight gain.
In cats with the more common effusive or ‘wet’ form of FIP, abdominal effusions rapidly disappeared, starting at around 10–14 days after commencing treatment.
Encouragingly, and somewhat unexpectedly, cats with non-effusive (‘dry’) FIP and older cats responded as well to GS-441524 treatment as did cats with effusive FIP and young cats. The safety profile of GS-441524 was likewise impressive.
Currently, 24 of the 26 cats remain healthy, with one having succumbed to FIP disease and one to unrelated heart disease. Eighteen of these cats underwent just one round of treatment; the remaining eight suffered disease relapses, but these were successfully treated with a further (in two cases, a third) round of treatment at a higher dose.
Previously the prospects for cats with FIP were bleak. In a review paper on FIP published in JFMS a decade ago, Professor Pedersen stated: "no treatment has proven effective in curing cats of FIP, in spite of the claims. Cats that develop FIP inevitably die of their disease in days, weeks or months."1
Now, as he approaches the end of his professional career, Professor Pedersen is considerably more optimistic: "FIP has been my fascination for the past 50 years and I am fortunate to have reached a final stage in my career having identified safe and effective antiviral drugs. We now know that small molecules targeting specific steps in RNA virus replication are capable of safely curing various forms of FIP."
However, he cautioned: "It must be emphasised that the field trial we report was for proof-of-concept and the results cannot be immediately translated into commercially available products.
"Unfortunately, the real hope provided by these initial trials has increased, and not decreased, the desperation of owners to seek out these new drugs on the black market. As eventful as these discoveries may be, there is still much more about FIP to discover.
"I would like to thank all of the people, organizations and owners who have assisted in my research over this half century and leave remaining questions and associated discoveries for my fellow FIP researchers."
Reference
Photo: Bubba, one of the study cats, in recovery. Courtesy Adel Gastle
Researchers say that whilst widely discussed, many in the profession may not be aware that prevalence of the disease has been steadily increasing across all regions of the UK.
Since November 2012, 177 cases have been reported, with more than 90% between November and May. However, the cause of CRGV, which often presents as ulcerations to the dog’s skin and can lead to acute kidney injury (AKI) and potentially death, remains unknown.
Practices are being now asked to report suspect cases in a bid to gain vital insight into the disease and what may be causing it.
David Walker BVetMed (Hons) DipACVIM DipECVIM-CA from Anderson Moores (pictured right) is helping lead the research: "CRGV is a disease that impacts lots of breeds across the UK. Reports show there is seasonality to the disease and therefore an environmental cause is a possible component in its development.
"This research is part of the puzzle and will hopefully help to guide further work on this disease. By collecting more information on confirmed cases, such as walking habits and diet, we hope to build more understanding in order to better protect pets and inform treatment decisions."
To gather this information, Anderson Moores is asking practices to share a 10-minute online survey with the owners of dogs in which CRGV has been confirmed, as well as some control dogs following criteria provided with the survey link.
David said: "Many pet owners are aware of this disease and are concerned for their pets; if they are asked to help they are usually happy to do so. By offering a direct link to the survey, very little of the veterinarian’s time is needed to collate the information."
If you have a suspected case of CRGV, contact Anderson Moores on 01962 767920 or email medicine@andersonmoores.com
If the pet does not survive, then histopathologic assessment of tissue will be performed free of charge to confirm the diagnosis.
In confirmed cases the veterinary surgeon will be sent a link to a 10-minute survey to be completed by the owner.
Along with encouraging the owner of the confirmed case to take part, four unaffected control cases from the same clinic, on the same day, will also need to be recruited.
When a set of five qualifying surveys (one confirmed case and 4 control cases) are provided, practices can claim an Amazon Echo Dot, provided by Bayer, as a thank you for helping with the research.
The programme offers a structured and heavily supported first year in practice, including hands-on surgical training and seminars from Advanced Veterinary Practitioners, at the Pets'n'Vets' Roundhouse Veterinary Hospital in Glasgow.
Totally Grad! also includes a mentor plan and additional monthly benchmarking and seminars and support.
Oliver Jackson, partner at Pets'n'Vets said: "We are well aware that many larger veterinary entities run new graduate programmes and we are proud to say that Totally Grad! offers great advantages that come with our independent structure.
"Independent practice can offer a rewarding working environment for new graduates – particularly progressive practices such as ours. We can offer new graduates not only the close-knit, friendly, helpful, stable, first-opinion experience, but also provide opportunities for career growth and development.
"We have the facility for graduates to explore their particular areas of interest. Indeed, in our practice it is possible for a new graduate to change our way of working – the decision-makers are available and listening. We now have many vets working with us who have come through the practice from our graduate system and who have gone on to help shape our practice.
"The success of our Laparoscopic and Cardiology clinics can be attributed to those vets, as can various other client service initiatives and ways of working. New blood brings new ideas and we welcome that."
Totally Grad! will also be open to fellow independent practices.
Oliver added: "By opening up our Totally Grad! programme, we are offering a simple, accessible facility to those fellow independent practices able and willing to provide a mentor and allow their graduate vets to be out of their practice for one or two days per month over a 12 month period. It fits perfectly with our Roundhouse Referrals offering which offers advice, CPD and support to local practices."
Any independent practices interested in participating in the programme can contact oliver.jackson@petsnvets.org while final year students interested in learning more about the programme can visit the website at www.totallygrad.co.uk and/or email Karen W at hello@totallygrad.co.uk
Lynne was instrumental in creating the Linnaeus business in January 2015, and then growing it to the point where it now has 145 veterinary practices across the UK.
Lynne will be staying on as a consultant for Mars Petcare, which acquired Linnaeus in June 2018. She said: "As much as I would love to be part of the continuing journey and success of Linnaeus, I feel it is right for me to step back from the total time commitment required to be a CEO."
Paul Coxon, Linnaeus Chief Financial Officer, said: "The Linnaeus Group’s achievements under Lynne’s leadership cannot be underestimated. Since 2015, there have been numerous development milestones and significant growth as we have welcomed a number of highly-regarded referral centres and exceptional first opinion brands to the Linnaeus family. Lynne leaves us with a great legacy and a very bright future."
Linnaeus is due to make an announcement on Mrs Hill’s successor shortly.
In its updated position statement, the association emphasises its support of current UK legislation and says it would like to see improved implementation of current laws, in particular when informed by an evidence-based welfare outcomes approach.
The BVA also recommends that any proposals to improve welfare during transport should embrace all forms of transport and include welfare issues before, during and after movement. This, it says, would help ensure that a well-defined set of animal welfare standards are met for the entirety of any journey.
The BVA recommends that animals are slaughtered as close to the point of production as possible and supports the exploration of further opportunities which would assist this. It recognises that transportation of live animals can be unavoidable in some situations – for example, journeys between the Scottish Islands and Highlands – but says that no animal should be exported to a destination with unknown welfare standards, to one using systems currently banned in the UK or to a country where it would be slaughtered without stunning.
BVA President Simon Doherty said: "Any kind of movement has the potential to impact on an animal’s health and welfare. Ideally, we’d like to see livestock slaughtered close to the point of production, as long as all legislative health and welfare standards can be maintained. However, we recognise the high standards of welfare in the UK and support better implementation of current legislation.
"We have taken care to reiterate that any improvements made to live animal transport should consider welfare issues before, during and after movement so that a more complete approach is taken on this issue.
"We recognise that journey length is not the only influencer of welfare conditions for animals, and transport needs to be looked at as a whole rather than focusing on single factors. The most important thing for Government to do is to consider the evidence base when it weighs up options for making improvements."
The company says it's not just older horses suffering from joint disease, 36% of horses developed the condition by the time they were eight years old.
In the survey, 69% of horses needed up to five visits to their veterinary surgeon for treatment, while 21% needed as many as ten visits. Horse owners spent an average of £2,104 treating their horse’s joint condition while 5% spent more than £7,500 on the problem.
In addition, 53% said they've missed up to ten competitions due to joint disease, with 17% missing more than 20 competitions.
The survey revealed that joint problems are an ongoing concern for many. 76% of owners said they worry about their horse developing osteoarthritis and 30% had retired a horse earlier than expected owing to joint disease. In addition, 84% admitted that they would not buy a horse if they knew it had joint problems.
In terms of joint care, 74% of respondents said they give their horse a joint supplement. 69% check their horse's legs daily and 90% implement post-competition leg care measures.
Cavalor’s Lieselot Hamerlinck said: "It is good to see that so many horse owners are using a joint supplement but it’s important that they understand what to look for when choosing which product to use. They should look for anti-inflammatory products, not just joint support and for clinical evidence on any product claims. It’s not just about giving a joint supplement every day, it’s more about giving the right product tailored to the horse’s individual needs.
"Also horse owners should be mindful that it is equally important, if not more so, to take proper care of their horse’s joints all year round, not just during competition."
For further information, visit www.cavalor.com.
Chanelle's head of sales and marketing, Killian Gaffney said: "The total UK market is around 80,000 bottles annually. However, with the major supplier announcing some re-stocking in March but full availability still under question, there is a real sense of urgency for practitioners.
"The Chanelle team worked throughout December with our manufacturing division to ensure that the UK product shortfall could be alleviated.
"Air freighting supplies seemed the obvious course of action, and ensured we could supply the UK market as quickly as possible."
For further information, contact: Chanelle on 00353 91 841 788.
Jason has a very personal reason for supporting the charity: his wife is one of the 100 people diagnosed with MS each week: "My wife, Adele, was diagnosed with MS a few years ago and the support and information we have received from the MS Trust has been invaluable in helping us as a family to come to terms with the condition."
The MS Trust offers trusted information, a friendly voice to speak to and the funding and training of vital MS nurses. Each month the charity responds to on average 271 enquiries and sends out around 3,700 information booklets.
To support Jason's efforts, visit: uk.virginmoneygiving.com/jasondavidson
Henry Schein said in a statement on Friday that it had sold the business in order to focus on its dental and medical markets and pursue new investment opportunities.
Covetrus says it will be using the experience, technology and global scale of the merged companies to provide veterinary practices with a more comprehensive set of integrated services and technology solutions, and tools to strengthen client relationships and grow their practice.
Covetrus launched on Nasdaq last Friday, when President and Chief Executive Officer Benjamin Shaw, said: "Today marks an important new chapter in the world of veterinary medicine, as we launch Covetrus as a new company listed on Nasdaq.
"We look forward to strengthening our customer relationships and expanding our veterinary practice partnerships worldwide as we bring more comprehensive and powerful solutions to market to meet their evolving needs and improve health and financial outcomes."
The company says that so far, it has had no cases of flu reported in horses vaccinated with Equip F or Equip FT in the UK. However, it cautions that in the present flu outbreak it is not clear if any of the current influenza vaccines will provide complete clinical protection against the mutated strain.
In addition, Zoetis highlights that:
Equip F and Equip FT are both indicated for reduction in clinical signs caused by Equine Influenza, including Florida Clade 1 strains.
Cross protection has been demonstrated by virulent challenge for representative strains of Florida Clade 1 (Paillot et al 20081, Bryant et al 20102) and Clade 2 (Paillot et al 20153).
Vaccination with Equip F stimulated a flu specific cell-mediated immune response to a Clade 1 strain which was detectable for up to one year after the third vaccination in primary course (Paillot et al 20153).
Zoetis says it is confident that the Equip range continues to be effective against its licensed indications.
If you have further questions about the vaccines, ring 0845 300 8034 and choose option 1 to speak to Zoetis' technical team.
References
Veterinary nurses, veterinary surgeons, students and other veterinary professionals are all invited to take part in the anonymous survey and share incidents where they have witnessed discrimination or felt discriminated against.
The survey covers the nine protected characteristics under the Equality Act: age, gender reassignment, marital or partnership status, being pregnant, disability, race, religion, sex and sexual orientation. It also includes other forms of discrimination which might not fit under these characteristics, such as body weight and socio-economic background.
BVA Junior Vice President Daniella Dos Santos said: "The veterinary professions should be open, welcoming and supportive of everyone; however, it is clear from the reports we’re hearing that discrimination is still an issue. Worse still, we’re aware that some colleagues have faced a backlash when talking about their experiences of discrimination. This is completely unacceptable.
"If we hope to prompt meaningful change we need to fully understand the scale of the problems our colleagues are facing. To do that it’s important that we provide a safe, anonymous space for everyone to share their experiences. We hope this questionnaire will give people that opportunity and we would like to sincerely thank our colleagues for their willingness to share their personal experiences with us."
The survey was developed with the support of the British Veterinary Ethnicity and Diversity Society (BVEDS) and British Veterinary LGBT+.
BVA says it intends to gather further quantitative data on discrimination via its Spring Voice of the Veterinary Profession Survey 2019.
The questionnaire is open from 2 February until 2 March and should take around 10 minutes to complete. A link to the questionnaire is available here.
The new guidance is being launched as part of the company's Keeping Britain’s Pets Healthy (KBPH) preventative healthcare initiative.
The guidance includes 18 recommendations designed to help all members of the practice team to implement consistent, effective improvements in preventative healthcare.
The recommendations were the result of a package of research carried out by Dr Rachel Dean, Dr Marnie Brennan, Dr Natalie Robinson and Dr Zoe Belshaw at the university’s vet school, including a systematic review of the literature, a survey of veterinary surgeons and in-depth interviews with vets and owners. A final study used the Delphi technique to achieve consensus amongst 26 first opinion practitioners and 8 pet owners.
The recommendations invite practices to consider a number of ways they might improve the consultation process, including: the purpose of the consultation, the role of each member of the practice team, and how pet owner expectations should be addressed and communicated during the process.
John Helps, Senior Technical Manager at MSD Animal Health said: "Our new KBPH initiative marks a step change in our emphasis on preventative healthcare.
"It aims to champion the central role each member of the veterinary practice team plays as experts in educating and engaging our nation of pet lovers.
"These evidence-based guidelines are just the first step towards our increased emphasis on communicating the importance of the annual preventative health visit.
"They support the partnership between the practice and its clients around the health and welfare of their pets, and the significant contribution vaccines and parasiticides make to the health and welfare of their pets. They also help the whole team understand their specific role in the provision of preventative healthcare."
You can download the full recommendations here.
Supplies of the vaccine, which is indicated for the active immunisation for horses against equine arteritis, ran low at the end of last year when Zoetis' existing stock was due to expire without any new stock in place.
For further information, contact your Zoetis Account Manager or the Zoetis Technical Team on customersupportUK@zoetis.com or 0845 300 9084 choosing option 1.
The latest figures from 2017/18 reveal that over 120 million animals were slaughtered in England and Wales without being stunned first1.
In an open letter to Environment Secretary Michael Gove, the BVA and the RSPCA urge the UK Government to change legislation in England which currently allows non-stun slaughter for religious purposes, and provide further public transparency on this issue by releasing the comprehensive 2018 slaughter survey results, which Mr Gove himself signalled would be published by Autumn 2018.
Until such legislation is in place the RSPCA and BVA are calling for:
meat to be labelled with the method of slaughter, e.g. stunned or non-stunned, so consumers are fully informed about the meat that they are buying.
non-stun slaughter to only be permitted at levels that meet local religious community demand for this type of meat in the interests of limiting animal pain and suffering.
a ban on export of meat from non-stunned animals or live animals destined for non-stun slaughter.
an immediate post-cut stun for cattle, sheep, goats and deer to reduce the period of pain and distress.
The letter follows a recent, high profile decision to ban the slaughter of animals without prior stunning in the Flanders region of Belgium which came into force at the start of the year. Belgium joins several other European countries, including Iceland, Sweden, Switzerland and Denmark in making this decision, demonstrating that a full ban on non-stun slaughter is possible within EU law.
RSPCA chief executive, Chris Sherwood said: "Until there is a change in the law to end non-stun slaughter, there are several measures the UK Government could introduce to reduce the suffering involved in this practice. For example, by ensuring trade deals with other countries do not include non-stun meat or live animals for non-stun slaughter, clear labelling should be adopted to enable consumers to make an informed choice about the meat they buy and how it was slaughtered."
BVA President Simon Doherty said: "The UK Government has repeatedly stated it would prefer to see all animals stunned before slaughter but has taken no action to address this critical welfare issue that affects millions of animals every year. It is doubly disappointing that data that would have provided a valuable benchmark for levels of non-stun slaughter in the UK has yet to see the light of day despite assurances throughout last year that it would soon be made public.
"There is a huge groundswell of support for a ban on non-stun slaughter, and recent developments in Belgium show that decisive change is possible where public support is matched by political will. Michael Gove has made clear that he wants to maintain and build on the UK’s reputation as global leader on animal welfare; banning non-stun slaughter is a surefire way of showing he will deliver on this commitment.
"If slaughter without stunning continues to be permitted in the UK, then meat and fish from this source must be clearly labelled, to help customers make informed choices about the food that they buy and eat."
You can sign the open letter at: www.rspca.org.uk/endnonstun and join the online debate using the hashtag #EndNonStun.
Sarah Gasper, BEVA’S Learning Manager said: "Many of us on the BEVA education team understand exactly what it’s like to return to practice whether after a career break, paternity/maternity or sickness leave. We also understand the specific challenges of moving from mixed into equine practice.
"We have created these courses to help make the transition back to work as smooth as possible. We’ve tried to incorporate everything we wish we had had access to when we returned to practice!"
Reinvigorate your approach to equine practice will be held on 12th March 2019 at Lythe Hill Hotel, Haslemere. The lecture and forum based course will explore the latest advances in internal medicine, orthopaedics, and sports medicine, and how to apply them to develop evidence-based clinical approaches to common and emergency scenarios in practice.
Getting (back) into equine practice will be held on 13th March 2019 at Liphook Equine Hospital, Hampshire. This entirely practical day of CPD will all be about improving the confidence of established equine vets and for vets returning to work following a career break. The course will focus on the practical procedures that an established equine ambulatory vet might be expected to perform on a regular basis. In a new approach to CPD we are trialling a system where delegates can shape part of this unique CPD day for themselves, with an online poll pre-course to select from a choice of practicals.
Both courses will have childcare facilities to help support parents wishing to attend CPD.
BEVA will also be running a course on the fundamentals of sedation, field anaesthesia and castration on 27th and 28th March 2019 at World Horse Welfare, Snetterton, Norfolk. This 'hands-on' course is designed for new or recent graduates or those in mixed practice with varied levels of equine work. It comprises evening lectures on the first day to free up more time for hands-on training on day two. It will cover sedation and field anaesthesia required for common field surgery such as castration, both in theory and in a practical session, with the equine welfare charity venue able to provide a high number of colts for castration work. Nerve blocks and regional anaesthesia for other common procedures will also be covered on cadavers.
For further information on BEVA’s new CPD courses visit www.beva.org.uk/cpd
The company says the new product has been launched in response to demand from UK equine veterinary surgeons specialising in dentistry
Hexarinse for Horses is presented as a palatable, mint-flavoured, ready-to-use formulation in a five litre container.
Virbac says the antibacterial action of chlorhexidine supports the maintenance of oral health after dental procedures and may aid the management of periodontal disease, oral inflammation and the management of peripheral caries.
For further information, speak to your local Virbac territory manager or contact Virbac Limited on: 01359 243243 or enquiries@virbac.co.uk.
The dentistry group is one of a number of special interest groups being launched on VetSurgeon.org in the coming months which ALL members are invited to come and join.
The new groups make it much easier to find and follow content that interests you. More than that, they bring together members with a shared interest in the subject, thereby facilitating the sharing of information, experience and knowledge. To that end, expert contributors to the new dentistry group include: Pete Southerden, Norman Johnston, Bob Partridge and Evelyn Barbour-Hill.
As elsewhere on VetSurgeon.org, reading content in the new groups or participating in discussions can count towards a VetSurgeon.org CPD certificate. Just press 'Claim CPD' at the top of the page, then collect the record and certificate from your profile.
As elsewhere on VetSurgeon.org, there's also the opportunity for you to express your appreciation of shared information you've found helpful, by pressing the 'Thank you' button above content. We'll be rewarding those members who are most thanked by members of the site for their help.
The new groups have been set up partly in response to the growth in Facebook groups for vets and the need for VetSurgeon.org to offer added value over Facebook if it is to compete for your attention.
By virtue of the number of its numbers, Facebook probably can't be beaten for general 'chit chat'. But for clinical discussions, it has some serious flaws.
Firstly, there's minimal curation of content and it's more or less impossible to filter irrelevant stuff. Because of that, and because Facebook displays post excepts, rather than headlines, you can end up having to scroll as far as Australia to find stuff relating to your area of interest.
By contrast, the listings of latest content by title on VetSurgeon makes it much easier to scan the content and find the stuff that interests you, particularly now content is grouped by clinical discipline.
Perhaps even more importantly, it's impossible to see the professional qualifications of the person who replied to you on Facebook, so you don't necessarily know if they have the faintest idea what they are talking about. VetSurgeon profiles are visible to all, and allow members to display their postgrad veterinary qualifications, amongst other things.
Lastly, the way discussions on Facebook are 'threaded' makes it very, very difficult to refer back and find who said something useful (you remember someone said something, but then, on a busy thread, you may have to expand 20 or 20 threads to find the thing you were after). That's not just a pain in the derrière, it means that any valuable information shared by specialists and experts is too easily lost.
The bottom line is that if you're looking for general chat, Fleecebook may be your best bet. But if you have questions about specific clinical disciplines, VetSurgeon.org is where you'll find better answers, quicker.
The PFMA says the factsheets have been produced with nutrition experts in response to demand from industry professionals.
Nicole Paley, Deputy Chief Executive, PFMA said: "We launched our factsheet range just over a year ago to tackle and dispel many of the myths around pet food. The range now covers sixteen subjects and with over 3,400 downloads, they have proved to be a valuable resource for pet professionals at the front line of pet care.
"We decided to add the Vegetarian Diets Factsheet and Food Allergy and Intolerance Factsheet to our range in response to demand for clarification on these topics. Owners are exploring alternative diets and whilst cats are obligate carnivores, dogs are omnivores and can adapt to vegetarian diets. As with all diets, they need to be well-balanced and our factsheet contains top tips.
"The Allergy Factsheet explains the difference between allergies and intolerances, which are both adverse food reactions but are very different conditions requiring different advice from veterinary professionals."
To see the full range of PFMA factsheets, visit: pfma.org.uk/fact-sheets.
Their study, which was published in the research journal PeerJ at the end of last year1, investigated the effects of insulin on equine hoof lamellar cells in the laboratory.
The researchers say that high levels of insulin have been known for some time to cause acute endocrine laminitis, seen when ponies and certain types of horses graze lush pasture or consume a starch- or sugar-rich diet, or when they develop Cushing’s syndrome.
Many ponies and horses at risk of the condition produce large spikes of insulin in their blood stream after consuming meals high in non-structural carbohydrates (in particular starch and simple sugars) which indicates that this could be the way in which they succumb to acute endocrine laminitis.
The mechanism by which insulin can cause effects in the foot leading to laminitis has been the subject of much debate in recent years.
Hormones like insulin must interact with a specific receptor on the surface of cells in order to produce their effects. What has confused researchers in the past is that there appear to be no insulin receptors on the hoof lamellar cells (these cells give the lamellar tissues their strength and changes to their growth or structure weaken the bonds and cause laminitis).
The researchers considered the close similarities between insulin and a growth factor hormone called insulin-like growth factor -1 (IGF-1). There are receptors for IGF-1 on the lamellar cells, and the researchers speculated that high concentrations of insulin might be able to cross-stimulate these cells by activating the IGF-1 receptors. To investigate this possibility PhD student Courtnay Baskerville, together with her supervisor Professor Simon Bailey, developed a method for culturing lamellar epithelial cells in the laboratory, and incubated them with increasing concentrations of insulin.
They found that high concentrations of insulin stimulated the cells to proliferate. Furthermore, this effect could be prevented using an antibody that specifically blocks only the IGF-1 receptor. Further downstream effects within the cells were also shown. The changes seemed to occur mainly at very high concentrations of insulin. Similar concentration levels can be seen in ponies and horses with insulin dysregulation linked to Equine Metabolic Syndrome, but are not commonly seen in normal horses that are considered to be at lower risk of laminitis.
Further work is now ongoing to determine exactly how these cellular changes induced by sustained high insulin concentrations might cause laminitis. However, it seems that targeting the IGF-1 receptor may be an option for developing new drugs to prevent and treat laminitis.
Professor Simon Bailey said: "The information gathered in this study provides the equine industry worldwide with valuable insights into the causes of the common and serious condition of laminitis. The research group would like to acknowledge the support of the Waltham Centre for Pet Nutrition, in particular the involvement of Professor Pat Harris.”
Furthermore, the research found that among female dogs that had problems giving birth, French bulldog bitches are then 2.4 times more likely to undergo invasive caesarean sections than crossbred dogs.
This compared to brachycephalic bitches in general, which the RVC researchers found are 1.54 times more likely to need a caesarean compared with their longer-nosed pure breed or crossbred counterparts.
As part of the research, academics studied 20,000 bitches that required emergency treatment at 50 Vets Now veterinary clinics between 2012 and 2014.
Their findings, published in two papers in The Veterinary Record, highlight the substantial risks that bitches and their puppies face during the birthing process.
According to the first paper1, 3.7% of female dogs suffer from dystocia. Alongside French bulldogs, other pure breeds such as Boston terriers, chihuahuas and pugs, are also particularly at risk of birthing problems. Compared to crossbred bitches, Boston terriers are 12.9 times more likely to face birthing issues, pugs 11.3 times more likely and chihuahuas 10.4 times more likely.
The second paper2, which is available open access, examines the effects of difficult births more closely. It found that on average, 25% of puppies and 1.7% of the bitches do not survive problem births. Apart from the risk of death, problem births also mean that many bitches have to undergo painful and invasive surgery, with 48.6% of problem births needing caesarean surgery.
Bulldogs (also known as British Bulldogs), border terriers and golden retrievers were the top three breeds at risk of caesarean section once they have difficulty giving birth. Bulldogs are 7.6 times more likely, border terriers are 4.9 times more likely and golden retrievers are 4.1 times more likely to need the procedure compared with crossbreeds.
RVC veterinary epidemiologist and VetCompass researcher Dr Dan O’Neill said: "This new research is another piece of evidence suggesting that mankind may have gone too far in modifying dog breed shapes towards extreme conformation that can interfere with basic biological functions. We all need to fall back in love with dog-shaped dogs and move away from the current fascination with extreme-shaped dogs."
O’Neill, DG., O’Sullivan, AM., Manson, EA., Church, DB., McGreevy, PD., Boag, AK., Brodbelt, DC.(2019) Canine dystocia in 50 UK first-opinion emergency care veterinary practices: clinical management and outcomes Veterinary Record Published Online First:04 February 2019. doi: 10.1136/vr.104944.
Suitable for both puppies and adult dogs, Eradia is presented in a bottle with an award-winning1 'All-In-One Smart Cap' which stops the person administering the product from coming into contact with the solution, is child proof and offers flexible dosing options.
Available in 30ml and 100ml bottles to cater for all dogs, Eradia can be administered either directly into the mouth or on to food.
Virbac says that Eradia has been shown to be accepted by 100% of dogs2, thereby alleviating any possible problems administering metronidazole.
For more information, contact your Virbac Territory Manager.
The main changes announced today are:
In the future, the revalidation interval, which currently ranges from two to five years depending on the course, will be standardised at 4 years.
Currently, there is a two-month window in which Official Veterinarians (OV) can submit their final declarations, on completion of the course, if they want to set their next revalidation interval from the end of the window.
The revalidation window will be extended to a six-month period prior to the completion deadline date. If completed in this window, the date of the next revalidation would be taken from the deadline date and not the date of completion.
APHA is discussing ways of making invigilation more flexible, to help those working in sole-charge or remote practices. One option being investigated with course accreditation providers is remote invigilation, though this would come at extra cost.
All the multiple choice questions in the online exams are being reviewed to make sure they test the ability to perform the role, and in the future, candidates will be given more feedback at the end of the test (ie which questions they answered incorrectly).
In terms of CPD requirements, there will be clarification on what can be considered relevant CPD towards the 10 hours that need to be completed over the four-year timeframe.
Lastly, APHA has announced a raft of changes concerning course content, and that it will itself review all the courses to consider how the number of courses and topics can be rationalised, how to reduce the number of qualifications any OV might need and/or the time spent revalidating, and how to reduce the content without losing quality.
The BVA, which spearheaded the campaign for reform, has welcomed the announcement. Simon Doherty, BVA President, said: "We’re delighted that APHA has taken on board our members’ concerns with the current system and proposed improvements that should make the process much more fair and consistent while continuing to maintain high standards. This is a really crucial time for ensuring that the workforce retains skilled professionals and is at full strength to keep animal welfare standards high, protect public health and meet demand for export certification after Brexit.
"This piece of work is a shining example of what can be achieved when vets pull together to air concerns and make the case for change. We will continue to work closely with APHA to explore and put in place ways of making the revalidation process as fit for purpose as possible for this critical section of the workforce."
Full review: http://apha.defra.gov.uk/documents/ov/Briefing-Note-0519.pdf
Whilst you're here, take a moment to see our latest job opportunities for vets.
Dr Bohnen faced two charges. The first was that in March 2017, she failed to attend to Belle, a Cavalier King Charles Spaniel, in order to provide appropriate and adequate care including: assisting Belle with urination, monitoring her with a view to considering alternative treatment options, and monitoring her with a view to providing her owners with an update on her condition.
The second charge was that Dr Bohnen later claimed dishonestly that she had attended to the animal, both to the owners, in clinical records hospital records, in a note provided to colleagues and during internal disciplinary proceedings held at her practice.
At the outset of the hearing the Committee considered an application from Dr Bohnen for the hearing to be postponed as she was now based in her home country of South Africa, and said she could not apply for a visa to return to the UK until later in the year and internet access in her location was poor.
However, the Committee found that the RCVS had properly served the notice of inquiry to Dr Bohnen in accordance with the current rules, that she had had sufficient time and opportunity to apply for a visa since receiving the notice and that, in any case, she could remotely ‘attend’ the hearing via Skype or telephone if necessary by travelling to somewhere that did have adequate internet connectivity, and so it refused the application.
The Disciplinary Committee then considered the facts of the case and heard evidence from the owners of Belle, the clinical director of the practice that Dr Bohnen worked in at the relevant time and a veterinary nurse, who was a student doing her training at the practice during the time of the events in question.
Having considered all of the evidence, the Committee dismissed the parts of the first charge relating to considering alternative treatment options and updating the owners in relation to Belle’s condition. They did, however, find the charge proven in relation to Dr Bohnen failing to assist Belle with urination.
The Committee found all aspects of the second charge proven in its entirety after Dr Bohnen admitted in advance of the hearing, that her representations were false and misleading.
The Committee then went on to consider whether the second charge and the aspects of the first charge that were found proven amounted to serious professional misconduct both individually and cumulatively.
The Committee considered that Dr Bohnen’s conduct in failing to assist Belle with urination, whilst falling below the standard to be expected of a reasonably competent veterinary surgeon, did not amount to serious professional misconduct.
The Committee did however find that Dr Bohnen’s conduct with regards to the second charge constituted serious professional misconduct.
Professor Alistair Barr, chairing the Committee and speaking on its behalf, said: "The Committee considers that the respondent’s dishonesty was the prime aggravating factor in this case. Although overall it could be regarded as a single incident, the Committee has found that it involved the fabrication of a number of notes and clinical records in the immediate aftermath of the death of the dog, but, thereafter, the respondent continued to deny the falsity of the fabricated records that she had created up to and until the conclusion of her interview by the practice on 30 March 2017.
"During that time, the respondent had contacted the alarm company responsible for the security of the premises of the practice, to enquire whether the security system would record the times of the alarm being switched on and off. This indicated that the respondent’s dishonesty continued over a significant period of time, and that her persistence in sticking to her story became premeditated. In other words, the respondent’s conduct over this time indicated a clear attempt to deceive."
Regarding the sanction for Dr Bohnen, the Committee considered that the principle aggravating factors in the case were serious dishonesty towards both her colleagues and the owners of the dog and involved clear breaches of the Code of Professional Conduct. By way of mitigation, the Committee noted that Dr Bohnen is of previous good character with no other professional findings against her and that she had demonstrated some insight into her behaviour and had admitted being dishonest and misleading prior to the hearing.
Summing up, Professor Barr said: "Because of the seriousness of this case, the Committee did not consider that it was appropriate to postpone judgement, take no further action, or to administer a reprimand and warning as to future conduct. The Committee considered that the respondent’s conduct, involving significant and admitted dishonesty over a period of time, required a significant penalty, in order to protect the welfare of animals and to serve the public interest.
"Accordingly, the Committee has decided to direct that the respondent’s registration be suspended for a period of nine months."
Dr Bohnen has 28 days from being informed of the Committee’s decision to lodge an appeal with the Privy Council.
This list was originally prepared BVDA President, Alex Smithson after being asked by lots of colleagues which dentistry CPD he knows of or recommends.
To his list, we've also added events hosted by Improve International and Bob Partridge.
In addition to the following courses, Orosurgeon Ltd provides in-house, group and individual training throughout the year. Courses can cover all dentistry and oral surgery topics, basic to advanced, including restorative & endodontic dentistry.
Contact admin@orosurgeon.co.uk for details.
In its statement, the company blamed the situation on the poor performance of 24 practices it bought in the Netherlands, and its new farm and equine divisions.
CVS says that another important factor has been employment costs, in particular the increase in market rates for locum veterinary surgeons and nurses on which it remains heavily reliant.
The company also blames its financial performance on the poor support of pharmaceutical companies, which it says it is continuing to push for transparent and 'appropriate' pricing.
Aside from trying to drive down the costs of drugs, the company says it has introduced 'additional procedures' designed to reduce the cost of employing locums, although it didn't specify what these are.
The group is also reevaluating its pipeline of acquisitions, in particular the multiples it is prepared to pay.
At the time of writing, the CVS share price had dropped over 28% to 465p overnight and 70% since the share price peaked at 1477p in November 2017.
In the game of acquisitions musical chairs, did the music just stop?
Full trading statement.