The researchers say that the findings pave the way to generating new and important information about the development chronic kidney disease (CKD) and hypertension (HTN) in cats.
The RVC says that about 30% of cats aged 10 years or older have CKD, which equates to approximately 600,000 in the UK.
Of these, about 40% will also have hypertension.
The research team was led by principal investigator at the RVC, Dr Rosanne Jepson, alongside joint first author from Queen Mary University of London, Dr Helen Warren, and Professor Patricia Munroe.
The team examined the archives of 1,022 domestic cats seen at both the RVC’s Beaumont Sainsbury Animal Hospital and Bow PDSA Pet Hospital since 1992, looking for genetic associations with CKD and HTN using a genome-wide association study (GWAS) approach.
The GWAS approach used a special feline array to characterise over 63,000 genetic differences across the feline genome.
The team examined the influence of different genes on disease traits which may point to new ways of treatment as the pathways and proteins controlled by these genes can indicate novel mechanisms for disease development.
Researchers say that this study method has historically been used for rarer and breed-specific conditions where single genetic mutations might be occurring.
However, the findings show it could now be used to generate new information about common and complex diseases which are likely to be the result of genetic, lifestyle and environmental risks.
Rosanne Jepson, Principal Author of the paper and Associate Professor in Small Animal Internal Medicine at the RVC, said: “This was an exciting opportunity to explore potential genetic influences on the development of chronic kidney disease and systemic hypertension in cats, collaborating with key opinion leaders who work and have published extensively in this field in human medicine.
“These conditions are complex - meaning that there are many factors relating to genetics, lifestyle and environment that cumulatively determine whether an individual may develop either CKD or hypertension in their lifetime.
“This study has shown us, as proof of concept, that large scale genomic studies will be important for understanding the pathogenesis of such complex disease conditions and may help to identify novel pathways as targets for diagnosis and management in the future.”
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