The outbreak, which was widely covered in the media, caused concern amongst cat owners.
The findings of an investigation found a link between high concentrations of trichothecene T-2/HT-2 mycotoxins (both poisonous substances, produced by fungi) in certain cat foods.
The first study, published in the Journal of Veterinary Internal Medicine, describes 580 cats recorded by the RVC’s database during the initial outbreak, the epidemiology of the cases and the link with mycotoxin exposure.
The cats presented with severe reductions in vital blood cells, including white blood cells responsible for fighting infection and platelets responsible for blood clotting.
The research recounts how analysis of these cats’ data – provided both by pet owners and vets - revealed three diets that had been consumed by the majority of affected cats and how this subsequently led to a UK wide recall in June 2021.
Examining the subsequent analysis of the feed samples and the discovery of mycotoxin contamination, which is known to be toxic to bone marrow, and thereby negatively impacting the production of key blood cells, the study concludes that mycotoxin contamination should be considered as the cause of the outbreak.
The second study examines 50 cats identified as having pancytopenia in more depth, providing a detailed picture of clinical findings to better understand the disease process in these cats affected by the outbreak.
Records and data of 50 of the affected cats were assessed to identify additional clinical signs which indicated contact with mycotoxins.
Following examination of the cats’ bone marrow, it was found that all cats suffered a marked toxic insult to their bone marrow.
From this, the study concluded that a differential diagnosis of mycotoxin-induced pancytopenia should be considered in cats presenting with pancytopenia.
Lead author of the research, Dr Barbara Glanemann, Senior Lecturer in Small Animal Medicine at the Royal Veterinary College and Co-head of the Small Animal Internal Medicine Service at the RVC’s Queen Mother Hospital for Animals, said:
“These pieces of research involved a great deal of work from many people (noted as authors and acknowledgements in the papers) and we really appreciate the teamwork involved, and the collaborative support we received.
“We know first-hand how much devastation and concern this outbreak caused for many cat owners across the country and so it is our hope that the studies will help people better understand what happened to cause this outbreak and can be used to not only provide some closure to those affected but also reduce the chances of something similar occurring in the future.”
References
PS: Whilst you're here, take a moment to see our latest job opportunities for vets.