A study published by Mike Dryden - one of the world's leading parasitologists - in Veterinary Parasitology has demonstrated that spinosad (Comfortis, Elanco) provides a high level of flea control one month after a single treatment and maintains a high level of effectiveness under conditions of natural challenge following subsequent monthly treatments.

The multi-clinic, investigator-blinded study¹ was undertaken in client-owned dogs provided with three consecutive monthly treatments of oral spinosad (SPN) and fipronil/methoprene spot-on (FSM). All other household dogs and cats, to a maximum of four pets per household, were dispensed the same treatment. Subsequent treatments were given when the dog returned for whole-body flea counts and pruritus-scoring on days 30 and 60, with final assessments on day 90 (plus/minus five days on each occasion).

One hundred and twenty eight dogs were enrolled on the study at 10 veterinary practices in the USA (65 in the SPN arm and 63 in the FSM arm). On day 0, mean flea counts were 57.7 (range: 10-1469) and 44.8 (range: 10-717) for the SPN and FSM groups, respectively. On day 90, 55 of the 58 (95%) SPN dogs were flea free compared with only 21/55 or 38% of dogs in the FSM group. Mean pruritus scores declined to 0.92 (6.67 on day 0) in the SPN group and 3.83 (6.33 on day 0) in the FSM group by day 90. Mean flea counts were 0.08 and 5.19 for SPN and FSM groups respectively on day 90 correlating to a reduction in flea counts of 99.9% in the SPN dogs and 88.4% in the FSM dogs. Between treatment differences were found to be highly statistically significant (p<0.0001) for every parameter measured at every time point during the study in favour of SPN.

Anna Jackson, national veterinary manager for Elanco Companion Animal Health said: "The recent study confirms oral spinosad's outstanding efficacy in controlling fleas and associated pruritus in dogs when administered by owners following natural challenge in the home environment".

For further information please contact your local Elanco Companion Animal Health key account manager or phone 01256 353131.

References

1       Assessment of owner-administered monthly treatments with oral spinosad or topical spot-on fipronil/(S)-methoprene in controlling fleas and associated pruritus in dogs.  Michael W. Dryden, William G. Ryan, Margie Bell, Anthony J. Rumschlag, Lisa M. Young, Daniel E. Snyder.  Veterinary Parasitology 191 (2013) 340-346

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