The Horse Trust is funding a three-year project to develop a genetic diagnostic test for Fell Pony Syndrome (FPS) and thus enable control and possible elimination of the disease.

The work will be undertaken at the Animal Health Trust, Newmarket, and the University of Liverpool Veterinary School.

The Fell pony, an ancient British pony breed categorised as "at risk" by the Rare Breeds Survival Trust, has over the past decade or so been subject to a severe immune deficiency known as Fell Pony Syndrome (FPS), which results in the death of some of the newborn foals.

Foals affected with FPS appear normal at birth but within a few weeks begin to lose condition and suffer diarrhoea, coughing and weight loss. Severe anaemia and immune dysfunction follows, leading to wasting and finally death. The disease is always fatal.

As a large percentage of these ponies live and breed on the fell, the prevalence of FPS is unclear. Despite an improvement in foal registration numbers in recent years, Fell Pony Syndrome remains of concern to breeders.

Studbook analysis and knowledge of affected foals strongly suggests that this is an inherited disease caused by an autosomal recessive genetic mutation. A DNA based test for this mutation would enable carriers of FPS to be identified and the conception of affected foals prevented.

As well as identifying carriers in the Fell pony population, the project will be used to identify any carriers in other breeds which have been involved in the extensive outbreeding of Fell ponies over the years.

"The success of this project will prevent the suffering of newborn Fell pony foals affected with FPS," says project leader Dr June Swinburne, senior post- doctoral equine molecular geneticist at the Animal Health Trust Centre for Preventive Medicine. "Foals affected by the condition inherit an incurable genetic defect which results in severe wasting and a profound anaemia together with multiple infections. Veterinary intervention is in vain and once the condition is diagnosed foals are often euthanased. The gradual but relentless decline in these foals leaves both veterinary surgeons and breeders powerless.

"Breeders are supportive of our attempt to develop a diagnostic test which will help to prevent carrier-carrier matings, one in four of which results in an affected foal."

The Horse Trust's Chief Executive and resident veterinary surgeon Paul Jepson said: "This is an exciting and achievable project with significant benefits for equine health and welfare, as it will lead to the prevention and elimination of a fatal disease."

PS: Whilst you're here, take a moment to see our latest job opportunities for vets.