The findings of a Canine Vector Borne Disease (CVBD) prevention field study, published in Veterinary Parasitology today, have demonstrated the efficacy of Advantix in repelling ticks and sandflies, thus reducing the risk of potentially deadly diseases.

The study, conducted over two years by a team headed by Professor Domenico Otranto of the Faculty of Veterinary Medicine (Universitá degli Studi di Bari) Italy, with diagnostic support from a team led by Dr. Edward Breitschwerdt at the North Carolina State University, USA, found that dogs treated regularly with Advantix spot-on had a greater than 90% reduction in CVBD cases, including a 100% reduction in new cases of potentially deadly leishmaniosis and a 94.6% decrease in ehrlichiosis.

The study also found that Advantix provided 97.9% protection against tick infestation, compared to untreated dogs, where 100% were infested at the peak of the season. The level of protection offered by Advantix was apparently all the more notable because of particularly large numbers of ticks and sand flies and high prevalence of associated diseases like leishmaniosis or babesiosis in the area of the study.

Prof. Otranto said: "Our study shows the importance of protecting dogs with an effective treatment that repels as well as kills parasites like ticks and sand flies. Despite the high challenge faced by the dogs in our study, nearly all our treated dogs remained free from ticks throughout most of the study, and more than 90% remained free from CVBDs for the whole study time.

"Because we included naïve sentinel beagles in the study, we were also able to model what would happen to dogs travelling to areas where CVBDs are present. We found that by the end of the study, only the Advantix-treated beagles remained protected from infection, while 80% of the untreated beagles were infected with a CVBD. This demonstrates the very real need to protect dogs that are travelling to endemic areas."

According to Bayer, the study showed some interesting results with dogs that were positive with CVBDs when they entered the study. Of these, half of those treated with Advantix were negative for CVBDs at the end of treatment, compared with only 13% of untreated dogs. This suggests the potential for natural clearance of CVBDs if a repellent treatment is used to prevent new transmissions.

Bayer says the study was extremely comprehensive, studying both indigenous and introduced naïve puppies, monitoring for several CVBDs and working with Dr. Breitschwerdt's team in the USA to use highly sensitive molecular testing techniques to ensure optimal diagnostic accuracy. Dr. Breitschwerdt said: "This is the most comprehensive study, to my knowledge, ever conducted testing the efficacy of a repellent ectoparasiticide to prevent the transmission of a spectrum of CVBDs in young dogs."

Leading parasitologist Dr. Luis Cardoso of the University of Trás-os-Montes e Alto Douro, Portugal said: "Thanks to this study we can see just how effective a treatment that repels as well as kills can be."

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