Intervet/Schering-Plough Animal Health has announced that it has received marketing authorization from the European Commission for a single-shot vaccination schedule of its Porcilis PCV vaccine against porcine circovirus type 2 (PCV2) infections.

The new approval allows vaccination with 1 dose of 2 ml in pigs from an age of 3 weeks onwards (known as the 1 - 2 - 3 approach) in the case of low to medium levels of maternal antibodies against PCV2, and also to include reduction of mortality as an additional indication. This new single-shot application for Porcilis PCV offers additional flexibility over the currently available dosage scheme of this vaccine, which has been available in Europe since April 2009.

Intervet/Schering Plough says the major characteristics of Porcilis PCV are that: (1) it contains the Cap-2 subunit antigen coded by ORF2 and therefore induces strong immunity against PCV2 infection; (2) it is combined with XSolve, an adjuvant offering immunity until the end of the finishing period; and (3) is able to break through of all levels of maternally-derived antibodies in piglets depending on the vaccination schedule used.

The company adds that one single dose of Porcilis PCV has been demonstrated to induce both humoral and cell-mediated responses against PCV2, despite the presence of low to medium levels of maternal antibodies. According to a recent study published in Vaccine, the immunity induced by a single dose of the vaccine resulted in reductions of viremia, viral shedding and viral load in tissues in vaccinated pigs as compared to controls. Field trials have also demonstrated that vaccination of pigs at 3 weeks of age or older reduces the presence of virus load in the blood and reduces weight loss associated with PCV2 infection during the fattening period.

Infection with PCV2 is known to cause a variety of syndromes in pigs, together known as Porcine Circo Virus Disease (PCVD). Symptoms may include clinical signs such as weight loss or failure to grow, enlarged lymph nodes, difficulty in breathing, pale skin and jaundice.

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